While diuretics used for bloating purposes can often be purchased OTC, prescription diuretics are used to help manage high blood pressure, among other health conditions. When taken alongside ibuprofen, however, they can negatively impact kidney function (via GoodRx). 2010 research published in the scientific journal Pharmaceuticals outlines how older adults, particularly those with health conditions like chronic kidney disease or cirrhosis of the liver, who also take a mix of medications, including certain antihypertensive drugs, diuretics, and NSAIDs, may be at an increased risk for kidney failure.
A 2022 study conducted by researchers at the University of Waterloo and published in Mathematical Biosciences revealed similar findings. Using digital simulations, the study team determined that people who utilize renin-angiotensin system (RSA) inhibitors (a type of blood pressure medication) and diuretics should be mindful about taking ibuprofen as it may increase these patients’ risk for potentially permanent kidney damage. “It’s not that everyone who happens to take this combination of drugs is going to have problems,” professor and researcher on the study Anita Layton stated via Science Daily. “But the research shows it’s enough of a problem that you should exercise caution.”