A 2011 meta-analysis in BMJ says that taking ibuprofen increases your risk of heart attack by 61%. If you weren’t taking ibuprofen before your heart attack, you probably shouldn’t start, according to a 2023 article in the European Heart Journal Cardiovascular Pharmacology. The study found that those who started using NSAIDs after their heart attack had a higher risk of experiencing a new heart attack, being admitted to the hospital for heart failure, or dying compared to those who didn’t take NSAIDs.
People who’ve experienced a heart attack might want to avoid ibuprofen or other NSAIDs because they can increase the risk of bleeding, according to a 2020 article in the Journal of the American College of Cardiology. The study found that taking ibuprofen after having a heart attack increases your risk of bleeding threefold compared to if you didn’t take the NSAID. If you need to take an NSAID, celecoxib (Celebrex) and meloxicam are safer options. GoodRx says that Tylenol is safe to use for pain, but like NSAIDs, you should avoid taking large doses.